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Metadefender for Chrome allows you to scan all downloads, or specific files, for malware using a number of commercial anti-malware engines in order to limit the potential of one slipping through.

Metadefender for Chrome will efficiently scan all the files you download from the web and make sure they aren't malicious. Protect your downloads, or specific files, from malware threats using 40+ commercial anti-malware engines. By using that many anti-malware engines the goal is to help ensure that more viruses, spyware, trojans, and other threats will be detected - malware that might be missed by a single anti-malware engine.

What's the Best Antivirus and Is Windows Defender Good Enough - 2018 Edition

Windows Defender Security Center - Sign in to Microsoft for Enhanced Security

Enable Windows Defender Application Guard for Microsoft Edge




Limitations:
This extension gives you the ability to scan downloads (up to 80 MB). You will need to set up a free account to receive your free API key which will let you check scan results for up to 1000 previously seen files per hour and scan up to 25 new or unknown files per hour.