The Logitech Setpoint runtime error is a common Logitech error, and here are some time-tested solutions to the problem.
1: Logitech Setpoint Runtime Error - Uninstall or Reinstall
Let me stop you here before you uninstall and or reinstall.
Windows comes with numerous mouse options making the Setpoint software pointless for most people. Many people think they need Setpoint for their mouse to work properly. You don't.
You can't get a Logitech Setpoint error if you don't have Setpoint installed. I prefer IOBit Uninstaller to be sure that the software is completely uninstalled.
If you want the Logitech Setpoint software, you can download for 32-Bit or 64-Bit operating systems.
Locate the Logitech executable causing the problem. Right-click on the file and click Properties. Click on the Compatibility tab. Choose an operating system under Run this program in compatibility mode for. You might need to try a few operating systems.