Clickless Mouse makes using a computer more accessible for users with repetitive strain injuries, carpal tunnel syndrome, some motor disabilities, and other health problems.
Gammy is an app similar to F.Lux, Lightbulb, the Windows 10 night light, and other similar screen temperature tools allowing you to dim or brighten your screen depending on the time of day, etc.
Angle Mouse is a free, portable app that runs quietly in the background and improves the efficiency and ease of mouse pointing, especially for people with motor impairments.