ccPortable (CCleaner via PortableApps) is a portable easy-to-use, safe, well-known drive cleaner with other additional features including a conservative registry cleaner, startup manager, and more. Video tutorial available. CCEnhancer can extend the cleaning capabilities of CCleaner.
ccPortable uses the same familiar three-tab interface; it always has the first tab showing you the main choices, including Cleaner, Registry, Tools, and Options. The second tab lets you choose any settings before you run it. The third tab shows you what is happening and what was done.
The drive cleaner and registry cleaner are both conservative in scope. There are drive cleaners out there that can clear more space if needed, but they aren't as safe as ccPortable. While we don't recommend cleaning your registry, again, ccPortable (CCleaner) is very conservative, and we've never had an issue after thousands of uses.
Under Tools, you can find many other tools to clean and speed up your PC more. There's an uninstaller, startup manager, browser plugin manager, system restore and drive wiper. It also has a disk analyzer to see where space is being wasted and a duplicate file finder.
Finally, many more options allow you to whitelist cookies, include or exclude files or folders, monitoring, and more.