DeSmuME is an open source Nintendo DS emulator. It sports tools designed for hackers, speedrunners, YouTubers, and casual gamers.
Homebrew programs are supported and can even be debugged through GDB.
The Windows versions are relatively feature rich, and there is a small universe of forks and mods that add even more features for casual gaming.
DeSmuME is the origin of RetroArch and OpenEmu Nintendo DS support and is used by several mobile Nintendo DS emulators, with the notable exception of DraStic.
MAME (Multiple Arcade Machine Emulator) was designed to allow you to enjoy old arcade games on your current machine. Also available as front ends: MAMEUI, IV/Play and Emu Loader.
Wii U USB Helper 0.6.1.655 [ 2018-05-01 05:42:03 | 1.47 MB | Freeware | Win 10 / 8 / 7 / Vista / XP / Android | 4 ]
Wii U USB Helper allows you to download, backup and play games from the eShop servers on your PC and Android. Project has been abandoned.
Emu Loader is an Open Source GUI for popular game emulators including MAME, Supermodel - Sega Model 3, Daphne, Demul, HBMAME, DICE, Sega Model 2 and ZiNc.