RogueKiller is an anti-malware app for advanced users capable of removing stubborn malware based on a list of signatures and heuristic analysis. Command line version available.
It is thus able to detect and remove a broad range of known and unknown malware. Its capabilities make it an outstanding tool to eliminate the most resistant infections, like rootkits.
Therefore, using RogueKiller is particularly recommended for malware removal, but it can also be used to ensure the operating system's integrity. Indeed, no risk of conflict with an existing antivirus is to be expected.
Roguekiller is a popular and useful tool to remove some stubborn malware, but be warned; you better know what you're doing. Malwarebytes is better suited for the home user. While many more popular tools will only scan and delete for you, this tool will show you everything it finds that is a possible problem. You need to know what to remove and what not to remove, or you could delete something you want or need. Your results may vary, but use caution and do your homework before removing anything or ask someone who is computer savvy.