SlickRun provides free instant access to any program or website via the command-line.
The SlickRun utility is displayed in a free-floating form to make access easy no matter what you are doing and where you are doing it.
Create specific command aliases (known as MagicWords), for instance, C:\Program Files\Outlook Express\msimn.exe becomes MAIL - this will dramatically cut down on keystrokes when trying to access frequently used programs or sites.
Please note, SlickRun is not a "hotkey" program. If you want a program that lets you press some wacky keyboard shortcut (say, Shift + Win + 1) to run to something, you'll want to find a different utility.