WinKill can disable your Windows key with one-click.
WinKill is primarily aimed at gamers who hit the Windows key when playing. It is portable and sits in your system tray using almost no resources. You can spot WinKill by the Windows logo which has a simple red X over it when activated. Click it to activate or deactivate, or you can do it the "hard way" by right clicking and select "Toggle."
WinKill is small, free, and simple to use for any gamer being annoyed by their Windows key. It was tested by the author on Windows 7, Vista and XP. It worked for us on Windows 10.